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The recommended dosage of BRAFTOVI is 450 mg (six 75 mg capsules) orally once daily in combination with binimetinib until disease progression or unacceptable toxicity. Refer to the binimetinib prescribing information for recommended binimetinib dosing information.
May 30, 2025 · This release contains forward-looking information about Pfizer Oncology and the BRAFTOVI® (encorafenib) plus cetuximab and mFOLFOX6 combination for the treatment of metastatic colorectal cancer (CRC) with a BRAF V600E mutation, including their potential benefits and discussions of the BREAKWATERsurvival data with regulatory authorities ...
Encorafenib is being investigated in combination with other agent (s) in the tumor types shown here. Safety and efficacy of encorafenib for the uses listed below has not been established.
1. BRAFTOVI® (encorafenib) Prescribing Information. Array BioPharma, Inc.; March 2025. 2. Center for Drug Evaluation and Research. Approved Drugs - Hematology/Oncology (Cancer) Approvals & Safety Notifications. Internet Archive Wayback Machine.
BRAFTOVI® (encorafenib) Clinical Pharmacology 12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Encorafenib is a kinase inhibitor that targets BRAF V600E, as well as wild-type BRAF and CRAF in in vitro cell-free assays with IC50 values of 0.35, 0.47, and 0.3 nM, respectively. Mutations in the medication page for patients to search for scientific information & …
May 30, 2025 · This release contains forward-looking information about Pfizer Oncology and the BRAFTOVI® (encorafenib) plus cetuximab and mFOLFOX6 combination for the treatment of metastatic colorectal cancer (CRC) with a BRAF V600E mutation, including their potential benefits and discussions of the BREAKWATERsurvival data with regulatory authorities ...
Learn about BRAFTOVI® (encorafenib) an Rx combination treatment for certain BRAF positive (BRAF+) cancer types and see risks & benefits.
Explore uses, dosage & safety info for BRAFTOVI® (encorafenib), a combination treatment.
May 30, 2025 · First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E–mutated metastatic colorectal cancer ...
4 days ago · Microsatellite stable BRAFV600E CRC is characterized by higher immune activation and clinically poor prognosis. Morris et al. demonstrate durable clinical benefit to encorafenib, cetuximab, and nivolumab in this phase 1/2 clinical trial. Extracellular vesicle and tumor RNA profiling both link specific immune activation signatures to treatment efficacy.
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